Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells

20/05/22 10:37

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Source https://science.sciencemag.org/
URL https://science.sciencemag.org/conten...
シェア日付 2020年05月22日(金) 10時37分21秒 +0900
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Supramolecular
言語 en
カテゴリー 学術

コンテンツ概要

Supramolecular attack particles Cytotoxic T cells (CTLs) are at the front lines against cancer and chronic infection. T cells kill by secreting caspase-activating granzymes and the pore-forming protein perforin from dense core granules. However, the structural basis of lethal hit delivery has remained unknown. Balint et al. enriched the synaptic output of CTLs to investigate the released form of perforin and granzyme B. They found that CTLs released perforin and granzymes in stable particles...